Resource Allocation for Downlink Multi-Cell OFDMA Cognitive Radio Network Using Hungarian Method

This paper considers the problem of resource allocation for downlink part of an OFDM-based multi-cell cognitive radio network which consists of multiple secondary transmitters and receivers communicating simultaneously in the presence of multiple primary users. We present a new framework to maximize the total data throughput of secondary users by means of subchannel assignment, while ensuring interference leakage to PUs is below a threshold. In this framework, we first formulate the resource allocation problem as a nonlinear and non-convex optimization problem. Then we represent the problem as a maximum weighted matching in a bipartite graph and propose an iterative algorithm based on Hungarian method to solve it. The present contribution develops an efficient subchannel allocation algorithm that assigns subchannels to the secondary users without the perfect knowledge of fading channel gain between cognitive radio transmitter and primary receivers. The performance of the proposed subcarrier allocation algorithm is compared with a blind subchannel allocation as well as another scheme with the perfect knowledge of channel-state information. Simulation results reveal that a significant performance advantage can still be realized, even if the optimization at the secondary network is based on imperfect network information

Immunoregulatory, proliferative and anti-oxidant effects of nanocurcuminoids on adipose-derived mesenchymal stem cells

Curcuminoids are dietary complexes extracted from the seeds of Curcuma longa L. that contain curcumin, bisdemethoxycurcumin and desmethoxycurcumin. Curcuminoids are popular for their pleiotropic therapeutic functions, such as their anti-inflammatory and anti-oxidant effects. Nonetheless, their clinical use is associated with poor systemic bioavailability and insolubility. The nano-formulation of curcuminoids eliminates these shortcomings. In the present study, we explored immunoregulatory, proliferative and anti-oxidant effects of nanocurcuminoids on adipose-derived mesenchymal stem cells (AT-MSCs). Flow cytometry analysis and MTT assay were employed to explore the effects of nanocurcuminoids on the apoptosis and proliferation of adipose-derived MSCs (AT-MSCs). The anti-oxidant effect of nanocurcuminoids on AT-MSCs also was examined. The immune regulatory effect of nanocurcuminoids was evaluated by the flow cytometric measurement of the T regulatory (Treg) population. The expression of inflammatory and anti-inflammatory cytokines was quantified using real-time PCR. Our findings demonstrate that low concentrations of nanocurcuminoids are beneficial for MSC proliferation, protection of MSCs from apoptosis, reducing inflammatory cytokines and SOD activity. A high concentration of nanocurcuminoids increases the population of Tregs and elevates the expression of TGFβ and FOXP3 genes. The beneficial effects of nanocurcuminoids on AT-MSCs were mainly observed at low doses of nanocurcuminoids